Endocrine Abstracts

Background: Subacute thyroiditis (SAT) is a destructive thyroiditis which is presumably caused by a viral infections or post-viral inflammatory response. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients may develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain unclear.Methods: A retrospective analysis of patients with SAT...

Background: Primary thyroid lymphoma (PTL) is a rare thyroid tumor that accounts for only 5% of thyroid malignancies, but is associated with higher mortality than differentiated thyroid cancer. The major risk factor for thyroid lymphoma is the presence of Hashimoto’s thyroiditis (HT) with an estimated 60-fold increased risk. The lymphocytic infiltrate in HT appears to develop into lymphoma in a minority of patients. The differential diagnosis between Hashimoto’s thyr...

Introduction: Immune checkpoint inhibitors have revolutionized the treatment of advanced malignancies. These monoclonal antibodies target cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death 1 (PD-1) or its ligand (PD-L1). Endocrine side effects are common, and while hypophysitis and thyroid disorders are predominant, checkpoint-blockade associated diabetes mellitus deserves further notice.Methods: We present the case of a 61-year old male wi...

Background: Monoclonal antibodies targeting CTLA-4 and PD-1/PD-L1 are promising for a wide range of advanced malignacies. These immune checkpoint inhibitors (ICI) provoke endocrine adverse events including hypopituitarism and primary thyroid disease.Methods: PubMed was searched through August 22nd, 2017, for relevant articles on endocrinopathies and ICI, by two reviewers independently (J.d.F. and C.A.). The weighted incidence and odds-ratio were estimate...

Background: Adrenal insufficiency is a rare but potentially life threatening complication of the antiphospholipid antibody syndrome (APS). The adrenal gland is the most commonly involved endocrine organ with adrenal insufficiency reported in 0.4% of APS cases. Adrenal failure more often follows other thromboembolic manifestations of APS.Case report: We report a 25-year-old male with systemic lupus erythematosus (SLE) with antiphospholipid syndrome (tripl...

Pheochromocytoma is a rare catecholamine-secreting tumor with variable clinical manifestations. A possible cardiac presentation is acute left ventricular wall motion abnormality in the heart also known as the Takotsubo syndrome. Takotsubo stress cardiomyopathy was first described in 1990 in Japan and current knowledge remains limited. We report a case of pheochromocytoma-induced Takotsubo syndrome. A 43-year-old woman acutely developed nausea, severe chest pain, and dyspnoea d...

Background: Risk factors for fragility fractures were assessed in several prediction models (e.g. FRAX®, Garvan, FRISBEE, …). The predictors of a shorter ‘time to first fracture’ and its impact on imminent fracture risk, however, remain to be determined.Methods: The concept of ‘time to first fracture’ between inclusion in the FRISBEE cohort (‘Fracture RIsk Brussels Epidemiological Enquiry’; 3560 postmenopausal wom...

Study Objective: Sevoflurane is a halogenated inhalational anesthetic increasingly used in the intensive care unit (ICU) for its potentially beneficial effects in patients with acute respiratory distress syndrome. However, safety data on prolonged sevoflurane sedation are lacking and cases of diabetes insipidus (DI) have been observed. The objective of this study was to assess the incidence and risk factors of DI during prolonged sevoflurane sedation.Des...

Background: Familial renal glucosuria (FRG) is a rare renal tubular disorder characterized by increased urinary glucose excretion despite normoglycemia. The sodium-glucose cotransporter 2 (SGLT2) is expressed in the proximal renal tubule and is crucial for glucose reabsorption. SLC5A2 is a member of the solute carrier family V transporter genes and encodes for this cotransporter. Mutations in SLC5A2 are the primary cause of FRG.Case pre...

Background : The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of an unprecedented scale, with an ever-growing impact on healthcare systems. The clinical presentation of coronavirus disease 2019 (COVID-19) is diverse, ranging from asymptomatic illness to respiratory failure requiring admission to the intensive care unit (ICU). Risk factors for severe presentation include old age, male gender, underlying comorbidities such as metabolic syndr...